For over 30 years, MTF Biologics has been focused on evolving processing technology with aseptic techniques. Aseptic processing ensures preservation of key biological matrices, cell attachment sites, and vital matrix proteins.
Terminal sterilization has been shown to alter tissue structure and matrix properties making cell infiltration and integration more difficult. The harsh treatment has also been shown to denature matrix proteins that are necessary for cell recruitment and differentiation.1
MTF Biologics requires strict ISO-certified clean rooms and batch/lot testing to confirm sterility assurance levels that conform to USP <71> standards.
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DePaula, C. A., et al. (2005). “Effects of hydrogen peroxide cleaning procedures on bone graft osteoinductivity and mechanical properties.” Cell Tissue Bank 6(4): 287-298
Han, B., et al. (2008). “Effects of gamma irradiation on osteoinduction associated with demineralized bone matrix.” J Orthop Res 26(1): 75-82.
Ijiri, S., et al. (1994). “Effect of sterilization on bone morphogenetic protein.” J Orthop Res 12(5): 628-636.
Munting, E., et al. (1988). “Effect of sterilization on osteoinduction. Comparison of five methods in demineralized rat bone.” Acta Orthop Scand 59(1): 34-38.