For over 30 years, MTF Biologics has been focused on evolving processing technology with aseptic techniques. Aseptic processing ensures preservation of key biological matrices, cell attachment sites, and vital matrix proteins.

Terminal sterilization has been shown to alter tissue structure and matrix properties making cell infiltration and integration more difficult.  The harsh treatment has also been shown to denature matrix proteins that are necessary for cell recruitment and differentiation.1

MTF Biologics requires strict ISO-certified clean rooms and batch/lot testing to confirm sterility assurance levels that conform to USP <71> standards.

MTF aseptically processed cortical matrix exposed to a terminal gamma radiation dose of 17.2 kGy; the osteoinductive potential in the three separate lots tested was reduced by approximately 50% 2
2 This information is based on 2017 data on file at MTF Biologics
Buring, K. and M. R. Urist (1967). “Effects of ionizing radiation on the bone induction principle in the matrix of bone implants.”Clin Orthop Relat Res 55: 225-234.
Chen, J. B., et al. (2007). “BMP-7 and CBFA1 in allograft bone in vivo bone formation and the influence of gamma-irradiation.” J Biomed Mater Res A 80(2): 435-443.
DePaula, C. A., et al. (2005). “Effects of hydrogen peroxide cleaning procedures on bone graft osteoinductivity and mechanical properties.” Cell Tissue Bank 6(4): 287-298
Han, B., et al. (2008). “Effects of gamma irradiation on osteoinduction associated with demineralized bone matrix.” J Orthop Res 26(1): 75-82.
Ijiri, S., et al. (1994). “Effect of sterilization on bone morphogenetic protein.” J Orthop Res 12(5): 628-636.
Munting, E., et al. (1988). “Effect of sterilization on osteoinduction. Comparison of five methods in demineralized rat bone.” Acta Orthop Scand 59(1): 34-38.