Not all bone grafts are created equally—and not all processing methods are, either. The way an allograft is processed can impact the structural and biologic characteristics that surgeons rely on in the operating room.
That’s why Kolosis proudly offers bone graft solutions processed by MTF Biologics, one of the most trusted and experienced names in the industry.
In a donor-matched study of DBM fibers, terminal irradiation caused dramatically accelerated total protein loss from the first 24 hours — with gamma-irradiated samples losing 3.9× more total protein than non-irradiated controls, and e-beam irradiated samples losing 3.6× more (p<0.0001). The burst release is immediate, and the sustained loss continues through day 42.2
Terminal irradiation doesn’t just accelerate protein loss — it compromises the structure that binds them. When irradiated DBM fibers were subjected to enzymatic digestion, significantly less tissue remained compared to non-irradiated controls, confirming increased susceptibility to degradation (p<0.05). Aseptic processing preserves both the proteins and the architecture designed to hold them.2
Processing methods can influence the integrity of a graft before it ever reaches the surgical site. Aseptically processed allografts are preferred by many surgeons because they are designed to preserve:
1 Shankar, G., Tabbaa, S., Davidson, E., El Naga, A. (2024, December 11-14) Both Terminal E-beam and Gamma Irradiation Negatively Impact Biological Properties of Demineralized Bone Matrices [Virtual Poster].Cervical Spine Research Society 52ndAnnual Meeting, Chicago IL.
2 Data on File, Kolosis
