Our Technologies

BOLD TECHNOLOGIES
FROM KOLOSIS BIO

Partnering exclusively with MTF Biologics, Kolosis is driven by its commitment to provide the very best allograft technologies to patients and clinicians.

Because Processing = Performance. ™

MTF’s proprietary aseptic processing ensures preservation of key biological matrices and vital matrix proteins.¹

Inductive

Head-to-head testing proves it: Kore Fiber has higher osteoinductivity than commercially available grafts from Medtronic, SeaSpine®, and Zimmer Biomet¹

Back-Table Ease

Once it’s in your hands, you’ll understand what we’re talking about. MTF fibers are moldable and versatile, while providing outstanding wet field integrity. Mitigate graft migration concerns with Kore Fiber.

Aspectically Processed

Terminal sterilization has been shown to impair mechanical functionality², reduce cell proliferation rates³, and considerably reduce osteoinductivity of cortical bone⁴.

¹ Data on File (MTF Biologics)
² Islam, A., et al. (2016). “Gamma Radiation Sterilization Reduces the High-cycle Fatigue Life of Allograft Bone.” Clin Orthop Relat Res 474(3): 827-835.
³ Han, B., et al. (2008). “Effects of gamma irradiation on osteoinduction associated with demineralized bone matrix.” J Orthop Res 26(1): 75-82.
⁴ Munting, E., et al. (1988). “Effect of sterilization on osteoinduction. Comparison of five methods in demineralized rat bone.” Acta Orthop Scand 59(1): 34-38.

PRE-HYDRATED, READY-TO-USE, AND PROVIDING OUTSTANDING HANDLING CHARACTERISTICS

Comprised of a proprietary formulation of elongated demineralized bone particles that are prehydrated in a preserved solution. Prime HD is supported by science and provides the biologic performance you have come to expect from MTF Biologics.

ASEPTIC ADVANTAGE

Terminal sterilization has been shown to alter tissue structure and matrix properties¹ making cell infiltration and integration more difficult. The harsh treatment has also been shown to denature matrix proteins that are necessary for cell recruitment and differentiation.²

MTF Biologics requires strict ISO-certified clean rooms and batch/lot testing to confirm sterility assurance levels that conform to USP <71> standards.

MTF aseptically processed cortical matrix exposed to a terminal gamma radiation dose of 17.2 kGy; the osteoinductive potential in the three separate lots tested was reduced by approximately 50%³

ACCESS THE KOLOSIS WHITE PAPER:

THE EFFECT OF IRRADIATION STERILIZATION ON DEMINERALIZED BONE MATRIX AND ALLOGRAFT TISSUE

¹ Islam, A., et al. (2016). “Gamma Radiation Sterilization Reduces the High-cycle Fatigue Life of Allograft Bone.” Clin Orthop Relat Res 474(3): 827-835.
² Munting, E., et al. (1988). “Effect of sterilization on osteoinduction. Comparison of five methods in demineralized rat bone.” Acta Orthop Scand 59(1): 34-38.
³ Data on File (MTF Biologics)

Why Choose MTF Grafts?

MTF Biologics is a global nonprofit and physician-led organization, headquartered in Edison, New Jersey. MTF Biologics has spent more than 30 years honoring donated gifts by developing innovative, effective allograft solutions to help people heal. From orthopedics to wound care to plastic and reconstructive surgery, MTF is a force in scientific progress and patient advocacy. Kolosis BIO partners exclusively with MTF for all tissue forms.

GET IN TOUCH

PHONE

(801) 662-0040

ADDRESS

Kolosis BIO, LLC
333 South Rio Grande St.
Salt Lake City, Utah 84101

EMAIL

[email protected]